-transparent.png){kind=logo}
Three murine monoclonal antibodies (anti-CD9: ALB6, anti-CD41: VI-PL3 and PL2-49/GPIIb - final concentration: 7.5 micrograms/mL) are shown to elicit after a lag time aggregation of washed platelets and a calcium signal (as detected by light emitted by loaded aequorin), which is only partially inhibited by aspirin. By comparison the rise induced by thrombin is greater and almost instantaneous. In the presence of EGTA a calcium mobilization from internal stores can be detected with thrombin and with ALB6, but neither with PL2-49 nor with VI-PL3, whereas platelets still change their shape and release ATP. It is tempting to speculate that although all the antibodies induce a calcium change, they activate platelets by different pathways: calcium may be not primarily involved in the activation induced by the anti-CD41 antibodies.
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
March 1990,
The Journal of biological chemistry,
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
June 1995,
The Journal of biological chemistry,
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
June 1991,
Thrombosis research,
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
September 1990,
Thrombosis research,
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
July 1997,
Thrombosis research,
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
September 1999,
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi,
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
August 1996,
Veterinary immunology and immunopathology,
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
October 1993,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
December 1996,
Journal of immunology (Baltimore, Md. : 1950),
R Favier, and
T Lecompte, and
M C Morel, and
F Potevin, and
P Benoit, and
C Boucheix, and
C Kaplan, and
M Samama
April 1988,
Revue francaise de transfusion et immuno-hematologie,
