Biomaterial Database

Igh allotype-linked control of immune complex-type hypersensitivity induced by hepatitis B surface antigen. 1989

H Y Lei, and S C Lee

Department of Microbiology, College of Medicine, National Cheng Kung University, Tainan, Taiwan, Republic of China.

Hepatitis B surface antigen (HBsAg) induced an immune complex-type hypersensitivity which developed at 5-6 hr after the challenge and could be transferred by anti-HBs antisera, in addition to the delayed-type hypersensitivity in B10.BR mice. The pre-S region of HBsAg influenced this induction because the pre-S-depleted HBsAg or recombinant major S protein could not stimulate this 5-hr ear swelling. The male B10.BR mice responded better than the female ones, probably due to the inhibition by female hormone. Furthermore, HBsAg could also induce an early-occurring hypersensitivity which appeared within 1 hr of the antigen challenge. However, B10.BR mice did not exhibit this hypersensitivity; B6 mice expressed all three types of hypersensitivity (1 hr, 5 hr and 24 hr) and BALB/c mice showed only 1-hr and 24-hr responses. The expression of the immune complex-type seems to be determined by the Ighb gene or gene(s) closely associated to it. Mice bearing the Igh-1b allotype could be stimulated by HBsAg to induce the immune-complex type hypersensitivity. Moreover, it was the high specific binding not the titre of anti-HBs antibodies that influenced the exhibition of immune complex-type hypersensitivity.

UI	MeSH Term	Description	Entries
D006967	Hypersensitivity	Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.	Allergy,Allergic Reaction,Allergic Reactions,Allergies,Hypersensitivities,Reaction, Allergic,Reactions, Allergic
D007126	Immunoglobulin Allotypes	Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES.	Allotypes, Immunoglobulin,Allotypic Antibodies,Antibodies, Allotypic,Ig Allotypes,Allotype, Ig,Allotype, Immunoglobulin,Allotypes, Ig,Allotypic Antibody,Antibody, Allotypic,Ig Allotype,Immunoglobulin Allotype
D007143	Immunoglobulin Heavy Chains	The largest of polypeptide chains comprising immunoglobulins. They contain 450 to 600 amino acid residues per chain, and have molecular weights of 51-72 kDa.	Immunoglobulins, Heavy-Chain,Heavy-Chain Immunoglobulins,Ig Heavy Chains,Immunoglobulin Heavy Chain,Immunoglobulin Heavy Chain Subgroup VH-I,Immunoglobulin Heavy Chain Subgroup VH-III,Heavy Chain Immunoglobulins,Heavy Chain, Immunoglobulin,Heavy Chains, Ig,Heavy Chains, Immunoglobulin,Immunoglobulin Heavy Chain Subgroup VH I,Immunoglobulin Heavy Chain Subgroup VH III,Immunoglobulins, Heavy Chain
D008297	Male		Males
D005260	Female		Females
D006514	Hepatitis B Surface Antigens	Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.	Australia Antigen,HBsAg,Hepatitis B Surface Antigen,Antigen, Australia
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000936	Antigen-Antibody Complex	The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.	Immune Complex,Antigen-Antibody Complexes,Immune Complexes,Antigen Antibody Complex,Antigen Antibody Complexes,Complex, Antigen-Antibody,Complex, Immune,Complexes, Antigen-Antibody,Complexes, Immune
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus