-transparent.png){kind=logo}
A metabolic view on menopause and ageing. 2014
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
1] Public Health Genomics Unit, Department of Chronic Disease Prevention, National Institute for Health and Welfare, Biomedicum 1, Haartmaninkatu 8, Helsinki 00290, Finland [2] Institute for Molecular Medicine (FIMM), University of Helsinki, Biomedicum 2, Tukholmankatu 8, Helsinki 00290, Finland [3] Department of Obstetrics and Gynecology, Helsinki University Central Hospital and University of Helsinki, Haartmaninkatu 2, Helsinki 00290, Finland [4].
The ageing of the global population calls for a better understanding of age-related metabolic consequences. Here we report the effects of age, sex and menopause on serum metabolites in 26,065 individuals of Northern European ancestry. Age-specific metabolic fingerprints differ significantly by gender and, in females, a substantial atherogenic shift overlapping the time of menopausal transition is observed. In meta-analysis of 10,083 women, menopause status associates with amino acids glutamine, tyrosine and isoleucine, along with serum cholesterol measures and atherogenic lipoproteins. Among 3,204 women aged 40-55 years, menopause status associates additionally with glycine and total, monounsaturated, and omega-7 and -9 fatty acids. Our findings suggest that, in addition to lipid alterations, menopause may contribute to future metabolic and cardiovascular risk via influencing amino-acid concentrations, adding to the growing evidence of the importance of amino acids in metabolic disease progression. These observations shed light on the metabolic consequences of ageing, gender and menopause at the population level.
Related Publications
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
June 1973,
Social science & medicine,
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
May 1973,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
December 1992,
Clinical obstetrics and gynecology,
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
January 2001,
The International journal of developmental biology,
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
January 1981,
Nursing times,
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
January 2022,
Therapeutic advances in endocrinology and metabolism,
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
January 1996,
Journal of the American Psychoanalytic Association,
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
December 2022,
Reproductive biomedicine online,
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
March 2009,
Menopause international,
Kirsi Auro, and
Anni Joensuu, and
Krista Fischer, and
Johannes Kettunen, and
Perttu Salo, and
Hannele Mattsson, and
Marjo Niironen, and
Jaakko Kaprio, and
Johan G Eriksson, and
Terho Lehtimäki, and
Olli Raitakari, and
Antti Jula, and
Aila Tiitinen, and
Matti Jauhiainen, and
Pasi Soininen, and
Antti J Kangas, and
Mika Kähönen, and
Aki S Havulinna, and
Mika Ala-Korpela, and
Veikko Salomaa, and
Andres Metspalu, and
Markus Perola
March 2022,
Nature microbiology,
