BIOMAT Database Logo BIOMAT Database Logo

Correlation between cerebral blood volume values and outcomes in endovascular therapy for acute ischemic stroke. 2015

Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Department of Neurosurgery, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA Department of Neurosurgery, Gates Vascular Institute, Kaleida Health, Buffalo, New York, USA.

BACKGROUND Neurointerventionalists do not agree about the optimal imaging protocol when evaluating patients with acute stroke for potential endovascular revascularization. Preintervention cerebrovascular blood volume (CBV) has been shown to predict outcomes in patients undergoing intra-arterial stroke therapies. OBJECTIVE To determine whether CBV can predict hemorrhagic transformation and clinical outcomes in patients selected for endovascular therapy for acute ischemic middle cerebral artery (MCA) stroke using a CT perfusion (CTP)-based imaging protocol. METHODS We retrospectively reviewed cases of acute ischemic stroke due to MCA M1 segment occlusion and correlated favorable clinical outcomes (modified Rankin scale (mRS) ≤2) and radiographic outcomes with preintervention CBV values. All patients underwent whole-brain (320-detector-row) CTP imaging, and absolute CBV values of the affected and contralateral MCA territories were obtained separately for the cortical and basal ganglia regions. RESULTS Relative CBV (rCBV) of the MCA cortical regions was significantly lower in patients with poor clinical outcomes than in those with favorable clinical outcomes (0.87±0.21 vs 1.02±0.09, p=0.0003), and a negative correlation was found between rCBV values and mRS score severity. rCBV of the basal ganglia region was significantly lower in patients with hemorrhagic infarction (p=0.004) and parenchymal hematoma (p=0.04) than in those without hemorrhagic transformation. CONCLUSIONS We found that cortical CBV loss is predictive of poor clinical outcomes, whereas basal ganglia CBV loss is predictive of hemorrhagic transformation but without translation into poor clinical outcomes. Our study findings support published results of baseline preintervention CBV as a predictor of outcomes in patients undergoing intra-arterial stroke therapies.

UI MeSH Term Description Entries
D007261 Infusions, Intra-Arterial Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease. Infusions, Regional Arterial,Infusions, Intra Arterial,Infusions, Intraarterial,Arterial Infusion, Intra,Arterial Infusion, Regional,Arterial Infusions, Intra,Arterial Infusions, Regional,Infusion, Intra Arterial,Infusion, Intra-Arterial,Infusion, Intraarterial,Infusion, Regional Arterial,Intra Arterial Infusion,Intra Arterial Infusions,Intra-Arterial Infusion,Intra-Arterial Infusions,Intraarterial Infusion,Intraarterial Infusions,Regional Arterial Infusion,Regional Arterial Infusions
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011859 Radiography Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film). Radiology, Diagnostic X-Ray,Roentgenography,X-Ray, Diagnostic,Diagnostic X-Ray,Diagnostic X-Ray Radiology,X-Ray Radiology, Diagnostic,Diagnostic X Ray,Diagnostic X Ray Radiology,Diagnostic X-Rays,Radiology, Diagnostic X Ray,X Ray Radiology, Diagnostic,X Ray, Diagnostic,X-Rays, Diagnostic
D001810 Blood Volume Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME. Blood Volumes,Volume, Blood,Volumes, Blood
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D002545 Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION. Cerebral Ischemia,Ischemic Encephalopathy,Encephalopathy, Ischemic,Ischemia, Cerebral,Brain Ischemias,Cerebral Ischemias,Ischemia, Brain,Ischemias, Cerebral,Ischemic Encephalopathies
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D005260 Female Females

Related Publications

Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Pre-intervention cerebral blood volume predicts outcomes in patients undergoing endovascular therapy for acute ischemic stroke.
May 2013, Journal of neurointerventional surgery,
Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Cerebral Small Vessel Diseases and Outcomes for Acute Ischemic Stroke Patients after Endovascular Therapy.
November 2022, Journal of clinical medicine,
Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Effects of Pretreatment Cerebral Blood Volume and Time to Recanalization on Clinical Outcomes in Endovascular Thrombectomy for Acute Ischemic Stroke.
July 2018, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association,
Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Endovascular therapy for acute ischemic stroke.
January 2009, Handbook of clinical neurology,
Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Endovascular therapy for acute ischemic stroke.
March 2009, Stroke,
Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
National trends in endovascular therapy for acute ischemic stroke: utilization and outcomes.
April 2020, Journal of neurointerventional surgery,
Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Acute ischemic stroke endovascular therapy.
January 2021, Handbook of clinical neurology,
Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Blood Pressure Trajectories and Outcomes After Endovascular Thrombectomy for Acute Ischemic Stroke.
March 2024, Hypertension (Dallas, Tex. : 1979),
Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Endovascular Therapy in Acute Ischemic Stroke: A Six-Year National Assessment of Utilization and Outcomes: Outcomes of Endovascular Therapy in Acute Stroke.
June 2025, The American journal of the medical sciences,
Maxim Mokin, and Simon Morr, and Andrew A Fanous, and Hussain Shallwani, and Sabareesh K Natarajan, and Elad I Levy, and Kenneth V Snyder, and Adnan H Siddiqui
Prediction of adverse outcomes by blood glucose level after endovascular therapy for acute ischemic stroke.
June 2011, Journal of neurosurgery,
Copied contents to your clipboard!