Biomaterial Database

Nongenomic, TRβ-dependent, thyroid hormone response gets genetic support. 2014

Karine Gauthier, and Frédéric Flamant

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, and Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon cedex 07, France.

UI	MeSH Term	Description	Entries
D002467	Cell Nucleus	Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	Cell Nuclei,Nuclei, Cell,Nucleus, Cell
D003593	Cytoplasm	The part of a cell that contains the CYTOSOL and small structures excluding the CELL NUCLEUS; MITOCHONDRIA; and large VACUOLES. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)	Protoplasm,Cytoplasms,Protoplasms
D006624	Hippocampus	A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.	Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013569	Synapses	Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.	Synapse
D058543	Class Ia Phosphatidylinositol 3-Kinase	A phosphatidylinositol 3-kinase subclass that includes enzymes formed through the heterodimerization of a p110 catalytic and a p85, p55, or p50 regulatory subunit. This subclass of enzymes is a downstream target of TYROSINE KINASE RECEPTORS and G PROTEIN-COUPLED RECEPTORS.	Class Ia Phosphatidylinositol 3-Kinases,Class Ia Phosphatidylinositol 3-Kinase, p110alpha Subunit,Class Ia Phosphatidylinositol 3-Kinase, p110beta Subunit,Class Ia Phosphatidylinositol 3-Kinase, p110delta Subunit,Class Ia Phosphatidylinositol 3-Kinase, p50alpha Subunit,Class Ia Phosphatidylinositol 3-Kinase, p55alpha Subunit,Class Ia Phosphatidylinositol 3-Kinase, p55gamma Subunit,Class Ia Phosphatidylinositol 3-Kinase, p85alpha Subunit,Class Ia Phosphatidylinositol 3-Kinase, p85beta Subunit,Class Ia Phosphatidylinositol 3-kinase, Regulatory, alpha Polypeptide,Class Ia Phosphatidylinositol 3-kinase, Regulatory, beta Polypeptide,Class Ia Phosphatidylinositol 3-kinase, Regulatory, gamma Polypeptide,Phosphatidylinositol 3-Kinase, Class Ia,Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide,Phosphoinositide-3-Kinase, Catalytic, beta Polypeptide,Phosphoinositide-3-Kinase, Catalytic, delta Polypeptide,Phosphoinositide-3-Kinase, Regulatory Subunit 1,Phosphoinositide-3-Kinase, Regulatory Subunit 2,Phosphoinositide-3-Kinase, Regulatory Subunit 3,alpha-P85 Subunit, PI-3K,p110alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase,p110beta Subunit, Class Ia Phosphatidylinositol 3-Kinase,p110delta Subunit, Class Ia Phosphatidylinositol 3-Kinase,p50alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase,p55alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase,p55gamma Subunit, Class Ia Phosphatidylinositol 3-Kinase,p85alpha Subunit, Class Ia Phosphatidylinositol 3-Kinase,p85beta Subunit, Class Ia Phosphatidylinositol 3-Kinase,Class Ia Phosphatidylinositol 3 Kinase,Class Ia Phosphatidylinositol 3 Kinase, p110alpha Subunit,Class Ia Phosphatidylinositol 3 Kinase, p110beta Subunit,Class Ia Phosphatidylinositol 3 Kinase, p110delta Subunit,Class Ia Phosphatidylinositol 3 Kinase, p50alpha Subunit,Class Ia Phosphatidylinositol 3 Kinase, p55alpha Subunit,Class Ia Phosphatidylinositol 3 Kinase, p55gamma Subunit,Class Ia Phosphatidylinositol 3 Kinase, p85alpha Subunit,Class Ia Phosphatidylinositol 3 Kinase, p85beta Subunit,Class Ia Phosphatidylinositol 3 Kinases,PI-3K alpha-P85 Subunit,Phosphatidylinositol 3 Kinase, Class Ia,Phosphoinositide 3 Kinase, Regulatory Subunit 1,Phosphoinositide 3 Kinase, Regulatory Subunit 2,Phosphoinositide 3 Kinase, Regulatory Subunit 3,p110alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase,p110beta Subunit, Class Ia Phosphatidylinositol 3 Kinase,p110delta Subunit, Class Ia Phosphatidylinositol 3 Kinase,p50alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase,p55alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase,p55gamma Subunit, Class Ia Phosphatidylinositol 3 Kinase,p85alpha Subunit, Class Ia Phosphatidylinositol 3 Kinase,p85beta Subunit, Class Ia Phosphatidylinositol 3 Kinase
D037042	Thyroid Hormone Receptors beta	High affinity receptors for THYROID HORMONES, especially TRIIODOTHYRONINE. These receptors are usually found in the nucleus where they regulate DNA transcription. They are encoded by the THRB gene (also known as NR1A2, THRB1, or ERBA2 gene) as several isoforms produced by alternative splicing. Mutations in the THRB gene cause THYROID HORMONE RESISTANCE SYNDROME.	Receptors beta, Thyroid Hormone,ERBA2 Gene Products,NR1A2 Gene Products,THRB Gene Products,TR beta,Thyroid Hormone Receptor beta,Thyroid Hormone Receptor beta-1,Thyroid Hormone Receptor beta-2,c-erbA beta,Gene Products, ERBA2,Gene Products, NR1A2,Gene Products, THRB,Thyroid Hormone Receptor beta 1,Thyroid Hormone Receptor beta 2,c erbA beta