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Pharmacokinetics and clinical studies on cefsulodin (CFS) were conducted in neonates. 1. MIC's of CFS, sulbenicillin and gentamicin (GM) were determined using 7 strains of Pseudomonas aeruginosa clinically isolated from neonates and maintained as stock cultures. CFS was found to be nearly as active as GM. 2. When CFS 20 mg/kg was administered to a 12-day-old neonate by intravenous bolus injection, serum concentrations were 8.7 micrograms/ml before administration and 51.7 micrograms/ml at 30 minutes, 44.4 micrograms/ml at 1 hour, 38.6 micrograms/ml at 2 hours and 11.1 micrograms/ml at 6 hours after administration. The half-life was 2.5 hours. 3. CFS was administered alone or combination with other drugs to 3 neonates. The drug was clinically effective in 2 cases and slightly effective in another. Bacteriologically, one case was rated as decreased, another as replaced, and the remaining one as unchanged. 4. Neither side effects nor abnormal laboratory values attributable to CFS were found.
S Iwata, and
Y Sato, and
M Tojo, and
Y Kusumoto, and
H Shiro, and
H Akita, and
S Nanri, and
T Oikawa, and
M Osano, and
S Kusano
March 1990,
The Japanese journal of antibiotics,
S Iwata, and
Y Sato, and
M Tojo, and
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H Shiro, and
H Akita, and
S Nanri, and
T Oikawa, and
M Osano, and
S Kusano
December 1989,
The Japanese journal of antibiotics,
S Iwata, and
Y Sato, and
M Tojo, and
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H Shiro, and
H Akita, and
S Nanri, and
T Oikawa, and
M Osano, and
S Kusano
October 1981,
The Japanese journal of antibiotics,
S Iwata, and
Y Sato, and
M Tojo, and
Y Kusumoto, and
H Shiro, and
H Akita, and
S Nanri, and
T Oikawa, and
M Osano, and
S Kusano
November 1982,
The Japanese journal of antibiotics,
S Iwata, and
Y Sato, and
M Tojo, and
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H Shiro, and
H Akita, and
S Nanri, and
T Oikawa, and
M Osano, and
S Kusano
December 1989,
The Japanese journal of antibiotics,
S Iwata, and
Y Sato, and
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S Kusano
November 1982,
The Japanese journal of antibiotics,
S Iwata, and
Y Sato, and
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S Kusano
November 1982,
The Japanese journal of antibiotics,
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January 1982,
Archives of oto-rhino-laryngology,
S Iwata, and
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January 1982,
Transactions - American Society for Artificial Internal Organs,
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The Japanese journal of antibiotics,
