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Administration of recombinant erythropoietin (r-HuEPO) is an effective treatment for the anaemia of chronic renal failure, but in some patients it has been accompanied by elevated blood pressure. This study focuses on seven patients with end-stage renal failure, managed on haemodialysis, who developed probable hypertensive encephalopathy with seizures during treatment with r-HuEPO. All made a full recovery. The events were not clearly related to the haemoglobin concentrations achieved, and four patients have subsequently been restarted on r-HuEPO therapy at a reduced dose, resulting in a slower increase in haemoglobin with no recurrence of episodes of severe hypertension. Close attention needs to be paid to blood pressure in patients commencing erythropoietin therapy, and it seems prudent to aim for a gradual increase in haemoglobin concentration to allow the circulation to adapt to changes in oxygen delivery and haematocrit.
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
September 1998,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
January 1994,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
March 2000,
Pharmacological research,
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
January 1995,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
January 1991,
VASA. Zeitschrift fur Gefasskrankheiten,
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
January 1991,
Contributions to nephrology,
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
August 1997,
Scandinavian journal of urology and nephrology,
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
February 1987,
Lancet (London, England),
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
January 1993,
International urology and nephrology,
M E Edmunds, and
J Walls, and
B Tucker, and
L R Baker, and
C R Tomson, and
M Ward, and
J Cunningham, and
R Moore, and
C G Winearls
July 2019,
Nephrology (Carlton, Vic.),
