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A technique of orthotopic liver transplantation in the pig is presented. The use of a veno-venous cava-portal-jugular shunt during the anhepatic phase helped by a roller pump with moderate systemic heparinization is described. Technical modifications of arterious and biliary anastomosis are described as well. This technique is not only similar to the procedure applied to man, but it also provides a safe and reproducible experimental model. It has produced good results according to a survival rate equal to 95% at 48 hour and 87.5% at one week in the orthotopic liver transplantation in the pig.
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