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A water-soluble polysaccharide-peptidoglycan complex (PSPG) was prepared from heat-killed Lactobacillus casei by digesting the bacteria with N-acetylmuramidase. The molecular weight of PSPG was over 30,000, and the polysaccharide portion of PSPG, its main component was composed of rhamnose, glucose, galactose, glucosamine and galactosamine. Mice pretreated intraperitoneally with PSPG survived after a lethal infection with Listeria monocytogenes or Pseudomonas aeruginosa. The growth of infecting bacteria (L. monocytogenes, P. aeruginosa, Salmonella typhimurium, Escherichia coli) in both the peritoneal cavity and the liver was inhibited markedly in the mice that had been treated with PSPG. It was suggested that macrophages may be the main effector for the anti-infectious effect of PSPG since treatment of mice with carrageenan, a selective macrophage blocker, markedly reduced the anti-infectious effect of PSPG.
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
June 1985,
Journal of clinical & laboratory immunology,
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
June 2005,
The Journal of nutrition,
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
March 1989,
Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases,
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
January 1988,
Microbiology and immunology,
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
January 1988,
Microbiology and immunology,
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
October 1997,
Journal of bacteriology,
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
January 1988,
Immunology,
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
January 1999,
Veterinary parasitology,
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
March 1971,
Archives of oral biology,
K Nomoto, and
M Nagaoka, and
T Yokokura, and
M Mutai
January 2017,
Frontiers in immunology,
