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Trimebutine meleate and metoclopramide increase small bowel motility. The present manometric study of the human normal interdigestive duodeno-jejunal motility demonstrated two different pharmacological effects in 15 healthy volunteers. Trimebutine constantly induced a premature phase 3 activity (0.81 +/- 0.4 min after a 100-mg intravenous injection) with patterns similar to spontaneous phase 3. Metoclopramide increased the motility index (contractile activity) during phase 2 without inducing a premature phase 3. No significant variations in plasma motilin concentration were noticed after either trimebutine or metoclopramide. The pancreatic polypeptide concentration rose significantly after metoclopramide injection.
S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
August 2000,
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S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
October 1984,
Nihon Heikatsukin Gakkai zasshi,
S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
May 2000,
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S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
May 1982,
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S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
June 1991,
Arzneimittel-Forschung,
S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
October 1999,
Academic radiology,
S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
July 1973,
Postgraduate medical journal,
S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
February 1983,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
December 1998,
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S Grandjouan, and
S Chaussade, and
D Couturier, and
D Thierman-Duffaud, and
J F Henry
February 1989,
Presse medicale (Paris, France : 1983),
