The publications considering multiple primary tumors date back even to the XIXth century, however the scientific interest towards this problem still remains significant. The classification of these tumors is changing through the years, and their frequency remains higher than the expected one. The colon is one of the organs, where multiple primary lesions are often found, as well as primary lesions, associated with extracolonic primary malignant tumors. The multiple primary tumors are still found to be a diagnostic challenge, while there is still no complete solidarity regarding the surgical treatment of lesions found simultaneously. The question whether the multiple primary lesions have a poorer prognosis as regards the survival rate, compared to the solitary tumors, has always aroused interest.