Centrosome positioning in polarized cells: common themes and variations. 2014

Julien Elric, and Sandrine Etienne-Manneville
Institut Pasteur - CNRS URA 2582, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France; Université Pierre et Marie Curie, Cellule Pasteur UPMC, rue du Dr Roux, 75015 Paris, France.

The centrosome position is tightly regulated during the cell cycle and during differentiated cellular functions. Because centrosome organizes the microtubule network to coordinate both intracellular organization and cell signaling, centrosome positioning is crucial to determine either the axis of cell division, the direction of cell migration or the polarized immune response of lymphocytes. Since alteration of centrosome positioning seems to promote cell transformation and tumor spreading, the molecular mechanisms controlling centrosome movement in response to extracellular and intracellular cues are under intense investigation. Evolutionary conserved pathways involving polarity proteins and cytoskeletal rearrangements are emerging as common regulators of centrosome positioning in a wide variety of cellular contexts.

UI MeSH Term Description Entries
D002450 Cell Communication Any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals carried by neurotransmitter substances, hormones, and cyclic AMP. Cell Interaction,Cell-to-Cell Interaction,Cell Communications,Cell Interactions,Cell to Cell Interaction,Cell-to-Cell Interactions,Communication, Cell,Communications, Cell,Interaction, Cell,Interaction, Cell-to-Cell,Interactions, Cell,Interactions, Cell-to-Cell
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D002465 Cell Movement The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell. Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016764 Cell Polarity Orientation of intracellular structures especially with respect to the apical and basolateral domains of the plasma membrane. Polarized cells must direct proteins from the Golgi apparatus to the appropriate domain since tight junctions prevent proteins from diffusing between the two domains. Cell Polarities,Polarities, Cell,Polarity, Cell
D018385 Centrosome An organelle near the nucleus of the cell consisting (in animals and organisms that have CILIA) of two CENTRIOLES, and the surrounding pericentriolar material. It functions as the primary MICROTUBULE-ORGANIZING CENTER during the eukaryotic CELL CYCLE (https://doi.org/10.1038/nrm2180). Pericentriolar Material,Pericentriolar Matrix,Pericentriolar Region,Centrosomes,Material, Pericentriolar,Matrix, Pericentriolar,Pericentriolar Materials,Pericentriolar Matrices,Pericentriolar Regions,Region, Pericentriolar

Related Publications

Julien Elric, and Sandrine Etienne-Manneville
January 2011, Trends in cell biology,
Julien Elric, and Sandrine Etienne-Manneville
September 2003, The Journal of cell biology,
Julien Elric, and Sandrine Etienne-Manneville
August 2016, Trends in genetics : TIG,
Julien Elric, and Sandrine Etienne-Manneville
August 2008, Trends in microbiology,
Julien Elric, and Sandrine Etienne-Manneville
February 2007, IUBMB life,
Julien Elric, and Sandrine Etienne-Manneville
May 2022, Cells,
Julien Elric, and Sandrine Etienne-Manneville
July 2016, Protoplasma,
Julien Elric, and Sandrine Etienne-Manneville
April 2005, Biochemistry,
Julien Elric, and Sandrine Etienne-Manneville
October 2010, The Biochemical journal,
Julien Elric, and Sandrine Etienne-Manneville
April 2018, Current opinion in cell biology,
Copied contents to your clipboard!