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The effects of centrally administered beta-endorphins on glucose homeostasis in the conscious dog were studied. Intracerebroventricular administration of beta-endorphin (0.2 mg/h) caused a 70% increase in plasma glucose. The mechanism of the hyperglycemia was twofold: there was an early increase in glucose production and a late inhibition of glucose clearance. These changes are explained by marked increases in plasma epinephrine (30-fold) and norepinephrine (6-fold) that occurred during infusion of beta-endorphin. Central administration of beta-endorphin also resulted in increased levels of adrenocorticotropic hormone and cortisol. In addition there was an increase in plasma insulin but no increase in plasma glucagon. Intravenous administration of beta-endorphin did not alter glucose homeostasis. Intracerebroventricular administration of acetylated beta-endorphin did not perturb glucose kinetics or any of the hormones that changed during infusion of the unacetylated peptide. We conclude that beta-endorphin acts centrally to cause hyperglycemia by stimulating sympathetic outflow and the pituitary-adrenal axis. Acetylation of beta-endorphin abolishes the in vivo activity of the peptide.
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
October 1995,
British journal of pharmacology,
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
July 2013,
American journal of physiology. Endocrinology and metabolism,
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
December 1990,
Metabolism: clinical and experimental,
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
July 1986,
Diabetes,
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
January 2013,
Diabetes,
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
June 1979,
British journal of pharmacology,
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
February 1993,
Metabolism: clinical and experimental,
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
January 1986,
NIDA research monograph,
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
July 2004,
Metabolism: clinical and experimental,
P M Radosevich, and
D B Lacy, and
L L Brown, and
P E Williams, and
N N Abumrad
May 2010,
American journal of physiology. Endocrinology and metabolism,
