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22Na+ uptake into capillaries isolated from the cerebral cortex of adult (20- to 26-week-old) sustained-hypertensive spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP) was compared with findings in age-matched Wistar Kyoto rats (WKY). In the presence of 1.0 mM ouabain, 1.0 mM furosemide and 2.0 mM LiCl, 22Na+ uptake into the isolated cerebral capillaries of WKY and SHR was significantly reduced to 38% and 65% of the control values, respectively, when 0.1 microM alpha-rat atrial natriuretic peptide (rANP) was added to the uptake buffer. The rANP-induced inhibition observed in SHR was significantly less, as compared with that in the WKY. Noteworthy was the observation that the Na+ uptake into the cerebral capillaries of SHRSP was not inhibited by rANP. As this peptide is thought to regulate amiloride-sensitive Na+ transport from the blood to brain by interacting with specific receptors, the present finding may relate to the etiology of dysfunction of the blood-brain barrier, in the presence of hypertension.
M Ibaragi, and
M Niwa, and
M Ozaki
November 1992,
American journal of hypertension,
M Ibaragi, and
M Niwa, and
M Ozaki
December 1991,
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M Ibaragi, and
M Niwa, and
M Ozaki
August 1992,
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M Ibaragi, and
M Niwa, and
M Ozaki
June 1990,
Brain research,
M Ibaragi, and
M Niwa, and
M Ozaki
October 1990,
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M Ibaragi, and
M Niwa, and
M Ozaki
February 1996,
Hypertension (Dallas, Tex. : 1979),
M Ibaragi, and
M Niwa, and
M Ozaki
March 1989,
The Journal of pharmacology and experimental therapeutics,
M Ibaragi, and
M Niwa, and
M Ozaki
July 1988,
American journal of hypertension,
M Ibaragi, and
M Niwa, and
M Ozaki
February 1990,
Hypertension (Dallas, Tex. : 1979),
M Ibaragi, and
M Niwa, and
M Ozaki
May 1991,
American journal of hypertension,
