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[Riboflavin supply of the Kara-Kalpak ASSr population with pathologic changes of the esophageal mucosa]. 1989

D G Zaridze, and Iu V Bukin, and V A Draudin-Krylenko, and Iu P Kuvshinov, and A D Dosshchanov

Riboflavin supply was studied in 164 adult inhabitants of the Kara-Kalpak ASSR where a high incidence of cancer of the esophagus and precancer changes of the esophageal mucosa were recorded. Endoscopy was used to investigate the morphological picture of the esophageal mucosa. A standard method for evaluation of the activation coefficient (AC) of erythrocytic glutathion-reductase (EC1.6.4.2) in the presence of FAD was used as a criterion of the body supply with riboflavin. Pronounced riboflavin deficiency (AC greater than or equal to 1.30) and B2 hypovitaminosis (AC = 1.20-1.29) were observed in 17 and 23% of the cases, respectively. Statistical analysis of the data obtained evidences that insufficient supply with riboflavin is recorded, on an average, 3.5-5.5 times more frequently in subjects with pronounced catarrhal esophagitis, combined with or without leukoplakia, than in the control group of subjects with out pronounced changes in the esophageal mucosa. No positive statistically significant association between low supply of the body with riboflavin and atrophic esophagitis has been established.

UI MeSH Term Description Entries
D009092 Mucous Membrane An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa. Lamina Propria,Mucosa,Mucosal Tissue,Muscularis Mucosae,Mucous Membranes,Membrane, Mucous,Membranes, Mucous,Mucosae, Muscularis,Mucosal Tissues,Propria, Lamina,Tissue, Mucosal,Tissues, Mucosal
D004912 Erythrocytes Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN. Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D004938 Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS. Cancer of Esophagus,Esophageal Cancer,Cancer of the Esophagus,Esophagus Cancer,Esophagus Neoplasm,Neoplasms, Esophageal,Cancer, Esophageal,Cancer, Esophagus,Cancers, Esophageal,Cancers, Esophagus,Esophageal Cancers,Esophageal Neoplasm,Esophagus Cancers,Esophagus Neoplasms,Neoplasm, Esophageal,Neoplasm, Esophagus,Neoplasms, Esophagus
D004947 Esophagus The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
D005980 Glutathione Reductase Catalyzes the oxidation of GLUTATHIONE to GLUTATHIONE DISULFIDE in the presence of NADP+. Deficiency in the enzyme is associated with HEMOLYTIC ANEMIA. Formerly listed as EC 1.6.4.2. Glutathione-Disulfide Reductase,Reductase, Glutathione,Reductase, Glutathione-Disulfide
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012257 Riboflavin Deficiency A dietary deficiency of riboflavin causing a syndrome chiefly marked by cheilitis, angular stomatitis, glossitis associated with a purplish red or magenta-colored tongue that may show fissures, corneal vascularization, dyssebacia, and anemia. (Dorland, 27th ed) Deficiency, Riboflavin,Deficiencies, Riboflavin,Riboflavin Deficiencies
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D014610 Uzbekistan A country in Central Asia, north of Turkmenistan, south of Kazakhstan. The capital is Tashkent. Uzbek S.S.R.,Republic of Uzbekistan,Uzbek SSR

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