BIOMAT Database Logo BIOMAT Database Logo

Heparin, heparan sulfate, smooth muscle cells, and atherosclerosis. 1989

M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Department of Pathology, Harvard Medical School, Boston, Massachusetts.

UI MeSH Term Description Entries
D009131 Muscle, Smooth, Vascular The nonstriated involuntary muscle tissue of blood vessels. Vascular Smooth Muscle,Muscle, Vascular Smooth,Muscles, Vascular Smooth,Smooth Muscle, Vascular,Smooth Muscles, Vascular,Vascular Smooth Muscles
D002455 Cell Division The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION. M Phase,Cell Division Phase,Cell Divisions,Division Phase, Cell,Division, Cell,Divisions, Cell,M Phases,Phase, Cell Division,Phase, M,Phases, M
D004730 Endothelium, Vascular Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components. Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D006025 Glycosaminoglycans Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine (see ACETYLGLUCOSAMINE) or N-acetylgalactosamine (see ACETYLGALACTOSAMINE). Glycosaminoglycan,Mucopolysaccharides
D006493 Heparin A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. Heparinic Acid,alpha-Heparin,Heparin Sodium,Liquaemin,Sodium Heparin,Unfractionated Heparin,Heparin, Sodium,Heparin, Unfractionated,alpha Heparin
D006497 Heparitin Sulfate A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS. Heparan Sulfate,Sulfate, Heparan,Sulfate, Heparitin
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000990 Antithrombin III A plasma alpha 2 glycoprotein that accounts for the major antithrombin activity of normal plasma and also inhibits several other enzymes. It is a member of the serpin superfamily. Heparin Cofactor I,Antithrombin III-Alpha,Atenativ,Heparin Co-Factor I,Kybernin,Serpin C1,Thrombate III,Antithrombin III Alpha,Antithrombin IIIAlpha,Cofactor I, Heparin,Heparin Co Factor I
D001161 Arteriosclerosis Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries. Arterioscleroses
D013329 Structure-Activity Relationship The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups. Relationship, Structure-Activity,Relationships, Structure-Activity,Structure Activity Relationship,Structure-Activity Relationships

Related Publications

M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Heparin causes the accumulation of heparan sulfate in cultures of arterial smooth muscle cells.
December 1996, Archives of biochemistry and biophysics,
M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Sulfation patterns in heparin and heparan sulfate: effects on the proliferation of bovine pulmonary artery smooth muscle cells.
November 2003, Biochimica et biophysica acta,
M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Cell surface heparan sulfate proteoglycan and chondroitin sulfate proteoglycan of arterial smooth muscle cells.
January 1992, The American journal of pathology,
M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Arterial smooth muscle cell heparan sulfate proteoglycans accelerate thrombin inhibition by heparin cofactor II.
September 1996, Arteriosclerosis, thrombosis, and vascular biology,
M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
An antiproliferative heparan sulfate species produced by postconfluent smooth muscle cells.
April 1985, The Journal of cell biology,
M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Antithrombin, heparin, and heparan sulfate.
May 2002, Critical care medicine,
M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Heparin and heparan sulfate biosynthesis.
October 2002, IUBMB life,
M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Heparin induces synthesis of highly charged heparan sulphate by vascular smooth muscle cells.
October 1990, Biochemical Society transactions,
M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Heparan sulfate proteoglycans control intracellular processing of bFGF in vascular smooth muscle cells.
September 1998, Biochemistry,
M J Karnovsky, and T C Wright, and J J Castellot, and J Choay, and J C Lormeau, and M Petitou
Biosynthesis of heparin and heparan sulfate.
January 1989, Annals of the New York Academy of Sciences,
Copied contents to your clipboard!