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The acute effect of inhibition of prostaglandin synthesis with indomethacin 50 mg by mouth on renal haemodynamics has been examined in 8 male Type 1 diabetic patients with elevated glomerular filtration rate who were free of diabetic complications. Renal plasma flow and glomerular filtration rate were measured by constant infusion of para-amino hippurate and polyfructosan, the patients being studied at normoglycaemia. Urinary excretion of prostaglandin E2 fell from 885 +/- 160 to 345 +/- 115 pg min-1, and excretion of 6-keto-prostaglandin F1 alpha fell from 489 +/- 77 to 283 +/- 50 pg min-1. There was no change in renal plasma flow or glomerular filtration rate following indomethacin. The results do not support the hypothesis that increased renal prostaglandin synthesis is a cause of hyperfiltration in diabetes mellitus.
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
April 1989,
Diabetic medicine : a journal of the British Diabetic Association,
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
January 2013,
PloS one,
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
January 1987,
Advances in prostaglandin, thromboxane, and leukotriene research,
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
January 1988,
Diabete & metabolisme,
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
May 2009,
Diabetes care,
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
January 2009,
Pediatric nephrology (Berlin, Germany),
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
May 2013,
Diabetologia,
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
September 2010,
Diabetes care,
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
November 1999,
The American journal of physiology,
D A Jenkins, and
K Craig, and
A Collier, and
M L Watson, and
B F Clarke
October 1998,
Clinical nephrology,
