Biomaterial Database

Vaccination against hepatitis B in homosexual men. A review. 1989

C Goilav, and P Piot

Department of Microbiology, Institute of Tropical Medicine, Antwerp, Belgium.

Homosexual men are at increased risk for infection with hepatitis B virus (HBV). Both plasma-derived and recombinant deoxyribonucleic acid vaccines have been shown to induce long-standing protective immunity in this population. However, non-responders and weak responders to HBV vaccine have recently become a problem among homosexual men because of an impaired antibody response due to previous infection with human immunodeficiency virus. In addition, human immunodeficiency virus infection predisposes persons to the development of a HBV carrier state following HBV infection. Vaccination still remains the most effective tool for preventing hepatitis B in homosexual men, although recent behavioral changes have apparently resulted in a decreased incidence of HBV infection among this group.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002986	Clinical Trials as Topic	Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.	Clinical Trial as Topic
D006509	Hepatitis B	INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.	Hepatitis B Virus Infection
D006510	Hepatitis B Antibodies	Antibodies to the HEPATITIS B ANTIGENS, including antibodies to the surface (Australia) and core of the Dane particle and those to the "e" antigens.	Anti-Australia Antigens,Anti-HBAg,Anti-Hepatitis B Antigens,Anti HBAg,Hepatitis B Virus Antibodies,Anti Australia Antigens,Anti Hepatitis B Antigens,Antibodies, Hepatitis B,Antigens, Anti-Australia,Antigens, Anti-Hepatitis B,B Antibodies, Hepatitis,B Antigens, Anti-Hepatitis,HBAg, Anti
D006716	Homosexuality	The sexual attraction or relationship between members of the same SEX.	Homosexuality, Ego-Dystonic,Ego-Dystonic Homosexuality,Homosexuality, Ego Dystonic
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor
D014611	Vaccination	Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis.	Immunization, Active,Active Immunization,Active Immunizations,Immunizations, Active,Vaccinations
D014761	Viral Hepatitis Vaccines	Any vaccine raised against any virus or viral derivative that causes hepatitis.	Hepatitis, Viral, Vaccines,Hepatitis Vaccines, Viral,Vaccines, Viral Hepatitis
D017325	Hepatitis B Vaccines	Vaccines or candidate vaccines containing inactivated hepatitis B or some of its component antigens and designed to prevent hepatitis B. Some vaccines may be recombinantly produced.	Hepatitis B Vaccine,Vaccine, Hepatitis B,Vaccines, Hepatitis B

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