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Burn injuries have been shown to impair immune function. One of the hypotheses for the etiology of the immunosuppression is that burn injuries result in an elevation of prostaglandin E (PGE) levels which then impair leukocyte function. We evaluated the effect of PGE levels on immune function in multiple animal models utilizing T cell subset levels for our immunologic measurements. Elevations in PGE levels were achieved by administering 16,16-dimethyl-prostaglandin E (dPGE) and reductions by administering indomethacin. The animal models included burned rats, burned-septic rats, and nonburned rats. Neither indomethacin nor dPGE administration resulted in alterations of any of the T cell subset populations in our models.
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
October 1990,
Journal of surgical oncology,
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
January 1989,
The Journal of burn care & rehabilitation,
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
November 1988,
Archives of surgery (Chicago, Ill. : 1960),
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
June 2014,
Multiple sclerosis (Houndmills, Basingstoke, England),
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
January 1985,
Investigative ophthalmology & visual science,
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
November 1988,
Memorias do Instituto Oswaldo Cruz,
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
September 1984,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
January 1992,
Internal medicine (Tokyo, Japan),
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
October 1984,
Clinical immunology and immunopathology,
J P Waymack, and
R F Guzman, and
D G Burleson, and
A T McManus, and
A D Mason, and
B A Pruitt
November 2018,
Molecular medicine reports,
