Biomaterial Database

[Effects of carbamylcholine and impromidine on cell cycle state of CFU-S]. 1989

X T Hu, and Y H Xu, and Y J Zhou

In normal steady-state conditions, there was less than 10% loss of CFU-S due to hydroxyurea (HU, 10(-3) mol/L). The CFU-S killed by HU was greatly increased after bone marrow cells of LACA mice were exposed in vitro to carbamylcholine (Cach) (10(-13)-10(-9) mol/L) and impromidine (Impro) (10(-9)-10(-4) mol/L). They were 32.8 (Cach) and 38.4% (Impro) for day 9 CFU-S; 60.6 (Cach) and 49.5% (Impro) for day 13 CFU-S at plateau phase. The effects were blocked by antagonists of cholinergic N receptor d-tubocurarine and of histamine H2 receptor cimetidine, respectively. The different sensitivity to agonists between CFU-S forming early spleen colonies and late colonies may reflect differences in receptor density on the surface of haemopoietic stem cells or receptor activity. The studies provide additional evidence suggesting the heterogeneity of pluripotent haemopoietic stem cells.

UI	MeSH Term	Description	Entries
D007093	Imidazoles	Compounds containing 1,3-diazole, a five membered aromatic ring containing two nitrogen atoms separated by one of the carbons. Chemically reduced ones include IMIDAZOLINES and IMIDAZOLIDINES. Distinguish from 1,2-diazole (PYRAZOLES).
D008297	Male		Males
D011970	Receptors, Histamine H2	A class of histamine receptors discriminated by their pharmacology and mode of action. Histamine H2 receptors act via G-proteins to stimulate ADENYLYL CYCLASES. Among the many responses mediated by these receptors are gastric acid secretion, smooth muscle relaxation, inotropic and chronotropic effects on heart muscle, and inhibition of lymphocyte function. (From Biochem Soc Trans 1992 Feb;20(1):122-5)	Histamine H2 Receptors,H2 Receptors,Receptors, H2,H2 Receptors, Histamine
D002217	Carbachol	A slowly hydrolyzed CHOLINERGIC AGONIST that acts at both MUSCARINIC RECEPTORS and NICOTINIC RECEPTORS.	Carbamylcholine,Carbacholine,Carbamann,Carbamoylcholine,Carbastat,Carbocholine,Carboptic,Doryl,Isopto Carbachol,Jestryl,Miostat,Carbachol, Isopto
D002453	Cell Cycle	The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.	Cell Division Cycle,Cell Cycles,Cell Division Cycles,Cycle, Cell,Cycle, Cell Division,Cycles, Cell,Cycles, Cell Division,Division Cycle, Cell,Division Cycles, Cell
D005260	Female		Females
D006146	Guanidines	A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
D006412	Hematopoietic Stem Cells	Progenitor cells from which all blood cells derived. They are found primarily in the bone marrow and also in small numbers in the peripheral blood.	Colony-Forming Units, Hematopoietic,Progenitor Cells, Hematopoietic,Stem Cells, Hematopoietic,Hematopoietic Progenitor Cells,Cell, Hematopoietic Progenitor,Cell, Hematopoietic Stem,Cells, Hematopoietic Progenitor,Cells, Hematopoietic Stem,Colony Forming Units, Hematopoietic,Colony-Forming Unit, Hematopoietic,Hematopoietic Colony-Forming Unit,Hematopoietic Colony-Forming Units,Hematopoietic Progenitor Cell,Hematopoietic Stem Cell,Progenitor Cell, Hematopoietic,Stem Cell, Hematopoietic,Unit, Hematopoietic Colony-Forming,Units, Hematopoietic Colony-Forming
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D017446	Impromidine	A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.	Impromidine Hydrochloride,Impromidine Oxalate (1:2),Impromidine Trihydrochloride,SK&F-92676,SKF-92676,Hydrochloride, Impromidine,SK&F 92676,SK&F92676,SKF 92676,SKF92676,Trihydrochloride, Impromidine