Photodynamic effects of zinc phthalocyanines on intracellular amastigotes of Leishmania amazonensis and Leishmania braziliensis. 2015

Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
Laboratório de Síntese Orgânica, Instituto de Pesquisa e Desenvolvimento, Universidade do Vale do Paraíba, 2911 Shishima Hifumi Avenue, 12244-000, São José dos Campos, SP, Brazil.

This study investigated the photoactivity of four zinc phthalocyanines (PcZns) on a murine macrophage cell line infected with Leishmania amazonensis or Leishmania braziliensis. Infected and uninfected cells were incubated with PcZns at different concentrations (1-10 μM) for 3 h and then exposed to an LED device in continuous wave mode at 660 nm with a fluency of 50 J/cm(2) (25 mV). Enzymatic activity was determined by MTT assay 24 h after light treatment. The results demonstrated that all PcZns exhibited high photoactivity, particularly when used at 10 μM. The photodynamic effects were different for uninfected cells versus parasite-infected cells and among the four PcZns. Uninfected cells were more sensitive to photoactivity than infected cells. Although PcZns photodynamic therapy provided promising results, further studies are necessary to better understand its mechanism of action in the treatment of leishmaniasis.

UI MeSH Term Description Entries
D007211 Indoles Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D007891 Leishmania A genus of flagellate protozoa comprising several species that are pathogenic for humans. Organisms of this genus have an amastigote and a promastigote stage in their life cycles. As a result of enzymatic studies this single genus has been divided into two subgenera: Leishmania leishmania and Leishmania viannia. Species within the Leishmania leishmania subgenus include: L. aethiopica, L. arabica, L. donovani, L. enrietti, L. gerbilli, L. hertigi, L. infantum, L. major, L. mexicana, and L. tropica. The following species are those that compose the Leishmania viannia subgenus: L. braziliensis, L. guyanensis, L. lainsoni, L. naiffi, and L. shawi. Leishmania (Leishmania),Leishmania (Viannia),Leishmania leishmania,Leishmania viannia,Leishmania leishmanias,Leishmania viannias,Leishmanias,Leishmanias (Leishmania),Leishmanias (Viannia),leishmanias, Leishmania,viannias, Leishmania
D007892 Leishmania braziliensis A parasitic hemoflagellate of the subgenus Leishmania viannia that infects man and animals. It causes cutaneous (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), and mucocutaneous leishmaniasis (LEISHMANIASIS, MUCOCUTANEOUS) depending on the subspecies of this organism. The sandfly, Lutzomyia, is the vector. The Leishmania braziliensis complex includes the subspecies braziliensis and peruviana. Uta, a form of cutaneous leishmaniasis in the New World, is caused by the subspecies peruviana. Leishmania (Viannia) braziliensis,Leishmania braziliensis braziliensis,Leishmania (Viannia) brasiliensis,Leishmania brasiliensis,Leishmania brasiliensis brasiliensis,Leishmania brasiliensis peruviana,Leishmania braziliensis peruviana,Leishmania viannia brasiliensis,Leishmania viannia braziliensis
D007896 Leishmaniasis A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL). Leishmania Infection,Infection, Leishmania,Infections, Leishmania,Leishmania Infections,Leishmaniases
D008264 Macrophages The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.) Bone Marrow-Derived Macrophages,Monocyte-Derived Macrophages,Macrophage,Macrophages, Monocyte-Derived,Bone Marrow Derived Macrophages,Bone Marrow-Derived Macrophage,Macrophage, Bone Marrow-Derived,Macrophage, Monocyte-Derived,Macrophages, Bone Marrow-Derived,Macrophages, Monocyte Derived,Monocyte Derived Macrophages,Monocyte-Derived Macrophage
D009942 Organometallic Compounds A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed) Metallo-Organic Compound,Metallo-Organic Compounds,Metalloorganic Compound,Organometallic Compound,Metalloorganic Compounds,Compound, Metallo-Organic,Compound, Metalloorganic,Compound, Organometallic,Compounds, Metallo-Organic,Compounds, Metalloorganic,Compounds, Organometallic,Metallo Organic Compound,Metallo Organic Compounds
D010778 Photochemotherapy Therapy using oral or topical photosensitizing agents with subsequent exposure to light. Blue Light Photodynamic Therapy,Photodynamic Therapy,Red Light PDT,Red Light Photodynamic Therapy,Therapy, Photodynamic,Light PDT, Red,PDT, Red Light,Photochemotherapies,Photodynamic Therapies,Therapies, Photodynamic
D002460 Cell Line Established cell cultures that have the potential to propagate indefinitely. Cell Lines,Line, Cell,Lines, Cell
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017319 Photosensitizing Agents Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms. Photosensitizer,Photosensitizers,Photosensitizing Agent,Photosensitizing Effect,Photosensitizing Effects,Agent, Photosensitizing,Agents, Photosensitizing,Effect, Photosensitizing,Effects, Photosensitizing

Related Publications

Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
April 2024, Photodiagnosis and photodynamic therapy,
Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
May 2004, Memorias do Instituto Oswaldo Cruz,
Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
March 2005, Parasitology international,
Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
June 2017, The Korean journal of parasitology,
Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
December 1988, Experimental parasitology,
Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
January 2022, Future microbiology,
Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
April 1988, Parasitology,
Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
November 2016, Natural product research,
Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
June 2005, Experimental parasitology,
Emanoel Pedro de Oliveira Silva, and Josane Mittmann, and Vitória Tonini Porto Ferreira, and Maria Angélica Gargione Cardoso, and Milton Beltrame
March 1998, Experimental parasitology,
Copied contents to your clipboard!