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Role of Wnt signaling in fracture healing. 2014
Huiyun Xu, and
Jing Duan, and
Dandan Ning, and
Jingbao Li, and
Ruofei Liu, and
Ruixin Yang, and
Jean X Jiang, and
Peng Shang
Key Laboratory for Space Biosciences & Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, Shaanxi Province 710072, People's Republic of China.
The Wnt signaling pathway is well known to play major roles in skeletal development and homeostasis. In certain aspects, fracture repair mimics the process of bone embryonic development. Thus, the importance of Wnt signaling in fracture healing has become more apparent in recent years. Here, we summarize recent research progress in the area, which may be conducive to the development of Wnt-based therapeutic strategies for bone repair.
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