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The antitumor effects of tegafur and UFT, fluorinated pyrimidines, were investigated in endometrial carcinoma bearing mice. Following administration of tegafur and UFT, each at a clinical dosage, the levels of 5-fluorouracil (5-Fu) and the inhibition of thymidylate synthase (TS) activity in the tumor tissue were measured. As a result, the mean levels of 5-Fu in the tumor tissue were approximately six times higher in the UFT group (29.2 +/- 10.7 ng/g) than in the tegafur group (4.9 +/- 4.8 ng/g) (p less than 0.01). The UFT group showed a mean inhibition of TS activity in the tumor tissue significantly higher (61.60 +/- 2.02%) than did the tegafur group (56.08 +/- 4.87%) (p less than 0.05). Hence, not only the higher tumor tissue levels of 5-Fu but also the higher inhibition of TS activity in the UFT group as compared with the tegafur group suggested that UFT had more potent antitumor effect.
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
March 1991,
Hinyokika kiyo. Acta urologica Japonica,
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
April 1987,
Biochemical pharmacology,
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
February 1991,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
November 1986,
Gan no rinsho. Japan journal of cancer clinics,
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
May 1989,
Cancer,
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
January 1995,
European journal of cancer (Oxford, England : 1990),
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
April 1990,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
June 1997,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
October 1988,
Cancer research,
M Suzuki, and
I Sekiguchi, and
T Tamada, and
M Nishida
January 1995,
Cancer investigation,
