Biomaterial Database

[A study on human T cells bearing IgG-Fc receptor in patients with bladder tumor]. 1989

T Fujiwara

IgG-FcR+-T cell ratio was measured in 50 patients with bladder tumor as a parameter to estimate the cell mediated immunity before the treatment. IgG-FcR+-T cell was detected by the double rosette method, employing sheep erythrocytes and rabbit IgG antibody coated chicken erythrocytes. IgG-FcR+-T cell ratio in 50 patients with bladder tumor was 7.6 +/- 5.7% (mean +/- standard deviation), while that in controls consisting of 20 patients with other diseases but bladder tumor was 5.2 +/- 2.4%. There was no significant difference between them. IgG-FcR+-T cell ratio in the group in early stages (pTa, pT1 & pT2) was 5.4 +/- 4.5%, and that in the group in advanced stages (pT3a, pT3b & pT4) was 10.8 +/- 6.0%.--significant difference between them (p less than 0.001)--. IgG-FcR+-T cell ratio in the low graded group (G0 & G1) was 5.5 +/- 4.4% and that in the high graded group (G2 & G3) was 9.7 +/- 6.2%.--significant difference between them (p less than 0.01)--. IgG-FcR+-T cell ratio in patients with the serum level of CEA over 2.6 ng/ml was 12.5 +/- 6.3% and that under 2.5 ng/ml was 5.6 +/- 3.7%.--significant difference between them (p less than 0.001)--. In patients having IgG-FcR+-T cell ratio over 9%, there was a correlation between IgG-FcR+-T cell ratio and PHA-induced lymphocyte blastogenesis ratio (r = -0.81, p less than 0.01). In patients with the serum level of CEA over 2.6% ng/ml, PHA-induced lymphocyte blastogenesis was decreased significantly and IgG-FcR+-T cell ratio was increased significantly. These findings suggest that serum CEA may play a role to proliferate the IgG-FcR+-T cells in association with an inhibition of PHA-induced lymphocyte blastogenesis.

UI	MeSH Term	Description	Entries
D007074	Immunoglobulin G	The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.	Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007111	Immunity, Cellular	Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.	Cell-Mediated Immunity,Cellular Immune Response,Cell Mediated Immunity,Cell-Mediated Immunities,Cellular Immune Responses,Cellular Immunities,Cellular Immunity,Immune Response, Cellular,Immune Responses, Cellular,Immunities, Cell-Mediated,Immunities, Cellular,Immunity, Cell-Mediated,Response, Cellular Immune
D008213	Lymphocyte Activation	Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.	Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009367	Neoplasm Staging	Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.	Cancer Staging,Staging, Neoplasm,Tumor Staging,TNM Classification,TNM Staging,TNM Staging System,Classification, TNM,Classifications, TNM,Staging System, TNM,Staging Systems, TNM,Staging, Cancer,Staging, TNM,Staging, Tumor,System, TNM Staging,Systems, TNM Staging,TNM Classifications,TNM Staging Systems
D011961	Receptors, Fc	Molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.	Fc Receptors,Fc Receptor,Receptor, Fc
D001749	Urinary Bladder Neoplasms	Tumors or cancer of the URINARY BLADDER.	Bladder Cancer,Bladder Neoplasms,Cancer of Bladder,Bladder Tumors,Cancer of the Bladder,Malignant Tumor of Urinary Bladder,Neoplasms, Bladder,Urinary Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Cancer, Bladder,Cancer, Urinary Bladder,Neoplasm, Bladder,Neoplasm, Urinary Bladder,Tumor, Bladder,Tumors, Bladder,Urinary Bladder Neoplasm
D002272	Carcinoembryonic Antigen	A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.	Antigens, CD66e,CD66e Antigen,Antigen, CD66e,Antigen, Carcinoembryonic,CD66e Antigens
D005260	Female		Females