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Reduced-dose (two-thirds) R-CHOP chemotherapy for elderly patients with non-Hodgkin lymphoma. 2015
Misato Kikuchi, and
Hideki Nakasone, and
Yu Akahoshi, and
Hirofumi Nakano, and
Tomotaka Ugai, and
Hidenori Wada, and
Ryoko Yamasaki, and
Kana Sakamoto, and
Koji Kawamura, and
Yuko Ishihara, and
Miki Sato, and
Masahiro Ashizawa, and
Kiriko Terasako-Saito, and
Shun-ichi Kimura, and
Rie Yamazaki, and
Shinichi Kako, and
Junya Kanda, and
Junji Nishida, and
Naohiro Sekiguchi, and
Satoshi Noto, and
Michiko Kida, and
Akira Hangaishi, and
Kensuke Usuki, and
Yoshinobu Kanda
Elderly patients with non-Hodgkin lymphoma (NHL) have a poor prognosis. Owing to treatment-related toxicities, there is no standard chemotherapy for the elderly patients, especially those aged 70 years or older. In this study, we retrospectively evaluated the efficacy and toxicity of reduced-dose (two-thirds) R-CHOP chemotherapy as an initial chemotherapy for 45 patients aged 70 years or older with B-cell NHL. The WHO classification of NHL included diffuse large B-cell lymphoma (DLBCL) (31), mantle cell lymphoma (5), follicular lymphoma (4), extranodal marginal zone lymphoma (1), Burkitt lymphoma (1), and B-cell lymphoma whose further types were unclassified (3). The incidences of grade 4 neutropenia and febrile neutropenia (FN) were 51.1 and 15.6%, respectively. Efficacy was evaluated in patients with DLBCL. The overall and complete response (CR) rates were 96.7 and 90.0%, respectively. Two-year event-free survival (EFS) and overall survival (OS) were 84.4 and 89.2%, respectively. There was no treatment-related mortality. In conclusion, two-thirds R-CHOP chemotherapy is a promising treatment for elderly patients with B-cell NHL in terms of its efficacy and toxicity.
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