-transparent.png){kind=logo}
Effects of cardiac pacing on secretion of atrial natriuretic polypeptide (ANP) were examined in 20 patients during cardiac catheterization under control conditions. The plasma ANP concentration in the coronary sinus (900 +/- 115 pg/ml) was significantly higher than those in the aorta (147 +/- 19 pg/ml) and the femoral vein (105 +/- 15 pg/ml) (p less than 0.001). The plasma ANP concentration was also significantly higher in the aorta than in the femoral vein (p less than 0.001). Its concentration at all three sites significantly increased during cardiac pacing (from 900 +/- 115 to 1461 +/- 218, from 147 +/- 19 to 250 +/- 36, and from 105 +/- 15 to 150 +/- 24 pg/ml, respectively). However, mean right atrial pressure and mean pulmonary capillary wedge pressure showed no significant changes between control conditions and during pacing (5 +/- 1 vs 6 +/- 1, and 8 +/- 1 vs 8 +/- 1 mmHg). Furthermore, there was no significant correlation between ANP secretion and the pressure in both atria. Thus, cardiac pacing can release ANP from the heart without increasing atrial pressure.
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
July 1989,
The American journal of physiology,
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
January 1989,
Journal of cardiovascular pharmacology,
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
May 1998,
Clinical and experimental pharmacology & physiology,
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
January 1990,
Circulation research,
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
August 1985,
Lancet (London, England),
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
May 1990,
Japanese heart journal,
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
September 1990,
The American journal of physiology,
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
April 1986,
Kokyu to junkan. Respiration & circulation,
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
January 1987,
Clinical and experimental pharmacology & physiology,
K Obata, and
H Yasue, and
K Okumura, and
K Matsuyama, and
H Ogawa, and
M Kurose, and
K Nakao, and
H Imura
August 1988,
The Journal of thoracic and cardiovascular surgery,
