Biomaterial Database

Effect of midline laparotomy on the cough reflex in dogs. 1989

G A Farkas, and M A Schroeder, and A De Troyer

Thoracic Disease Research Unit, Mayo Clinic, Rochester, MN 55905.

The present studies were designed to test the hypothesis that midline laparotomy promotes selective inhibition of the transversus abdominis muscle during cough as it does during expiratory threshold loading. Anesthetized dogs were studied in the supine posture, and cough was induced by mechanical stimulation of the airways. Midline laparotomy had virtually no effect on the cough-induced activation of the triangularis sterni or the external oblique. On the other hand, the activation of the transversus abdominis was markedly reduced in all animals. Despite this marked inhibition, however, peak pleural pressure and expiratory flow were preserved. This suggests that this inhibition does not play a significant role in determining the occurrence of bronchopulmonary infection after abdominal surgery.

UI	MeSH Term	Description	Entries
D007813	Laparotomy	Incision into the side of the abdomen between the ribs and pelvis.	Minilaparotomy,Laparotomies,Minilaparotomies
D010812	Physical Stimulation	Act of eliciting a response from a person or organism through physical contact.	Stimulation, Physical,Physical Stimulations,Stimulations, Physical
D012018	Reflex	An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
D003371	Cough	A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.	Coughs
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D000009	Abdominal Muscles	Muscles forming the ABDOMINAL WALL including RECTUS ABDOMINIS; ABDOMINAL OBLIQUE MUSCLES, transversus abdominis, pyramidalis muscles and quadratus abdominis.	Cremaster Muscle,Pyramidalis Muscle,Quadratus Abdominis,Transverse Abdominal,Transversus Abdominis,Abdominal Muscle,Abdominal, Transverse,Abdominals, Transverse,Abdomini, Quadratus,Abdominis, Quadratus,Cremaster Muscles,Muscle, Abdominal,Muscle, Cremaster,Muscle, Pyramidalis,Muscles, Abdominal,Muscles, Cremaster,Muscles, Pyramidalis,Pyramidalis Muscles,Quadratus Abdomini,Transverse Abdominals
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia