-transparent.png){kind=logo}
Two unusual peaks were found on gas chromatography of urine from four hyperammonemic patients treated with sodium benzoate. These peaks were identified by gas chromatography/mass spectrometric analyses as methylsuccinate and mesaconate. Of the two unusual substances, methylsuccinate was found to be a contaminant of sodium benzoate administered for the treatment of hyperammonemia. However, mesaconate was not a contaminant of sodium benzoate, though it could be detected in all urine samples from hyperammonemic patients treated with sodium benzoate. Mesaconate can be produced from methylsuccinate in vivo. Considering that mesaconate is an inhibitor of fumarase, the toxic effects of sodium benzoate may be attributable to the mesaconate. It is recommended that methylsuccinate-free sodium benzoate should be used for the treatment of hyperammonemia.
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
August 1983,
The Biochemical journal,
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
December 1999,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
March 1988,
Biochemical and biophysical research communications,
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
January 1990,
Diabete & metabolisme,
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
October 1985,
Clinica chimica acta; international journal of clinical chemistry,
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
September 1951,
Journal of the Irish Medical Association,
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
October 1950,
Klinicheskaia meditsina,
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
June 1991,
Lancet (London, England),
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
March 1982,
Journal of pharmaceutical sciences,
E Maeda, and
M Matsuo, and
K Saiki, and
H Nakamura, and
T Matsuo, and
H Takemine
September 1983,
The Journal of pediatrics,
