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The contractile properties of single rat cardiac myocytes isolated from normal and hypertrophied right ventricles have been investigated and then correlated with the isoenzyme pattern of ventricular myosin. The isoprenaline-stimulated contraction and the beta-adrenoceptor sensitivity were also investigated. Right ventricle hypertrophy was obtained by injecting monocrotaline, an alkaloid which induces severe pulmonary hypertension. The contractile parameters, namely contraction amplitude and speed of shortening, were obtained by means of an inverted microscope TV-system and edge-detection-device. Hypertrophied cells showed a significantly decreased speed of shortening and contraction amplitude when contraction was induced by maximum calcium and maximum isoprenaline. A statistically significant correlation existed between myosin alpha-chain percentage and both contraction parameters. Isoprenaline sensitivity expressed in terms of ED50, p kappa a and Hill coefficient were similar in the control and monocrotaline treated animals. Moreover no correlation between the degree of ventricular hypertrophy and ED50 existed. These results suggest that, in this animal model, the depressed contractile function which characterizes the hypertrophic myocardium depends on changes in isomyosin pattern while beta-adrenoceptor desensitization does not occur.
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
February 1993,
Cardiovascular research,
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
August 1994,
Shock (Augusta, Ga.),
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
June 1992,
Journal of hypertension,
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
December 1995,
Journal of hypertension,
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
January 1991,
Annals of the New York Academy of Sciences,
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
June 2021,
Internal medicine (Tokyo, Japan),
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
October 1971,
Archives internationales de physiologie et de biochimie,
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
February 2006,
American journal of physiology. Heart and circulatory physiology,
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
January 2001,
Acta physiologica Scandinavica,
G Vescovo, and
S E Harding, and
M Jones, and
L Dalla Libera, and
A C Pessina, and
P A Poole-Wilson
January 2007,
Methods in molecular medicine,
