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High-affinity uptake and localization of radiolabelled gamma-aminobutyric acid (GABA) has been examined using light microscopic autoradiography in laminar preparations and transverse paraffin sections of the rat stomach, and small and large intestine. In the presence of beta-alanine (10(-3) M), a substrate specific inhibitor of high-affinity GABA transport into glia, tritiated GABA was accumulated by a high-affinity uptake system into myenteric ganglia and a subpopulation of mucosal cells. In the small and large intestine high-affinity uptake of [3H]GABA was evident in myenteric ganglion cells, extra-ganglionic sites and in the deep muscular nerve plexus of the circular muscle layer. Such labelling could be prevented in tissue treated with the specific neuronal high-affinity uptake blocker, L-2,4-diaminobutyric acid dihydrochloride (L-DABA; 10(-3) M), and therefore represented the selective distribution of [3H]GABA uptake sites to intrinsic neuronal elements of the rat gastrointestinal tract.
A Krantis, and
T Webb
May 1975,
Experimental brain research,
A Krantis, and
T Webb
September 1970,
Brain research,
A Krantis, and
T Webb
February 1978,
Proceedings of the National Academy of Sciences of the United States of America,
A Krantis, and
T Webb
May 1985,
Neuroscience letters,
A Krantis, and
T Webb
January 1980,
Proceedings of the National Academy of Sciences of the United States of America,
A Krantis, and
T Webb
December 1973,
Brain research,
A Krantis, and
T Webb
March 1974,
Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948),
A Krantis, and
T Webb
January 1992,
Pharmacology,
A Krantis, and
T Webb
November 1987,
Brain research,
A Krantis, and
T Webb
February 1970,
Life sciences,
