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The origin and significance of anti-DNA antibodies. 1987
The Bloomsbury Rheumatology Department, University College and The Middlesex Hospital Medical School, London, UK; The Department of Internal Medicine D and Research Units of Autoimmune Diseases, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Polyreactive autoantibodies able to bind double-stranded DNA are a characteristic of systemic lucus erytheamtosus. Here, David Isenberg and Yehuda Shoenfeld discuss the likelihood that DNA is the immunogen in this disorder, and review a number of cross-reactions that may underline the detection of the antibodies.
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