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Long-term survival of non-small-cell lung cancer patients with EGFR inhibitor treatment. 2014
M X Zhang, and
W Tan, and
R X Zhang, and
Y L Tian, and
H M Gao, and
Z Gao, and
N Zhang, and
J Q Zhao, and
Y F Jia, and
Y S Wang
Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.
The epidermal growth factor receptor (EGFR) inhibitors gefitinib and erlotinib are effective in the treatment of advanced non-small-cell lung cancer (NSCLC), but the median survival of patients is short. Here, we describe 2 patients with NSCLC receiving conventional chemotherapy and alternative treatment with gefitinib or erlotinib as second-line therapy. The first patient was alive at 8 years with alternative conventional chemotherapy and gefitinib, and the second patient was alive at long-term follow-up with conventional chemotherapy and gefitinib or erlotinib. Gefitinib, erlotinib, and conventional chemotherapy can be combined for satisfactory therapy for NSCLC.
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