-transparent.png){kind=logo}
In neutrophils of patients with essential hypertension the NADPH-dependent O2- production elicited by stimulation with f-Met-Leu-Phe is three to four fold higher in comparison with neutrophils of normotensive control subjects. Neutrophils from hypertensive patients are less responsive to priming, by non-stimulating doses of the agonist, as compared to control cells, which following this pretreatment augment superoxide anion production up to levels close to those expressed by neutrophils from hypertensive patients. No difference in NADPH oxidase activity, between neutrophils from the two groups of subjects, was observed when the rate of O2- production was evaluated in a reconstructed cell-free system containing the membrane fraction and the cytosolic cofactors. These results are consistent with the hypothesis that differences in the functional organization of the oxidase at the membrane level in neutrophils of hypertensive are responsible for the enhanced O2- production following agonist stimulation.
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
May 1987,
The Journal of biological chemistry,
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
February 1988,
The Journal of biological chemistry,
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
December 1994,
Environmental health perspectives,
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
October 2002,
The Journal of asthma : official journal of the Association for the Care of Asthma,
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
May 1985,
Proceedings of the National Academy of Sciences of the United States of America,
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
September 1983,
Inflammation,
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
March 1999,
The Journal of infectious diseases,
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
January 1989,
Blood,
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
September 1990,
Biochimica et biophysica acta,
S Pontremoli, and
F Salamino, and
B Sparatore, and
R De Tullio, and
M Patrone, and
A Tizianello, and
E Melloni
August 1988,
Research communications in chemical pathology and pharmacology,
