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Seventeen patients using angiotensin-converting enzyme (ACE) inhibitors for hypertension were evaluated with baseline spirometry followed by determination of bronchial reactivity by challenge with methacholine. There were nine coughers and eight noncoughers in the study. Among the nine coughers, eight demonstrated bronchial hyperreactivity. Conversely, none of the noncoughers disclosed bronchial hyperreactivity. Eight of the nine coughers were rechallenged two to six months following cessation of ACE inhibitor therapy. Six of these eight showed persistent bronchial hyperreactivity. We conclude that cough is associated with the use of ACE inhibitors in patients with underlying bronchial hyperreactivity. The findings indicate caution in administration of ACE inhibitors in asthmatic patients and those with known bronchial hyperreactivity.
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
May 1991,
Medicina clinica,
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
January 1988,
British medical journal (Clinical research ed.),
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
September 1990,
Ear, nose, & throat journal,
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
April 1990,
The Journal of allergy and clinical immunology,
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
May 1999,
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego,
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
January 1989,
Journal of cardiovascular pharmacology,
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
November 1990,
Chest,
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
March 1987,
The New Zealand medical journal,
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
December 1987,
Lancet (London, England),
J Kaufman, and
J E Casanova, and
P Riendl, and
D P Schlueter
March 1988,
British medical journal (Clinical research ed.),
