BIOMAT Database Logo BIOMAT Database Logo

Transmitted antiretroviral drug resistance mutations in newly diagnosed HIV-1 positive patients in Turkey. 2014

Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
Clinical Laboratory, Kocaeli University, Kocaeli, Turkey.

BACKGROUND The objective of this study was to determine the transmitted drug resistance mutations (TDRMs) in newly diagnosed HIV-1 positive patients in Turkey. METHODS The study was carried out between 2009 and 2014 and antiretroviral naïve 774 HIV-1 infected patients from 19 Infectious Diseases and Clinical Microbiology Departments in Turkey were included; gender: 664 (86%) male, median age: 37 (range; 1-77), median CD4+T-cell: 360 (range; 1-1320) count/mm(3), median HIV-RNA load: 2.10+E6 (range; 4.2+E2-7.41+E8) IU/mL. HIV-1 drug resistance mutations were detected by population based sequencing of the reverse transcriptase (codon 41-238) and protease (codon 1-99) domains of pol gene of HIV-1, and analyzed according to the criteria by the World Health Organization 2009 list of surveillance drug resistance mutations [1]. RESULTS The patients had TDRMs to NRTIs (K65R, M184V), NNRTIs (K101E, K103N/S, G190A/E/S, Y181I/C, Y188H/L) and PIs (M46L, I54V, L76V, V82L/T, N83D, I84V, L90M). The prevalence of overall TDRMs was 6.7% (52/774). Resistance mutations were found to be 0.7% (6/774), 4.1% (32/774) and 2.1% (17/774) to NRTIs, NNRTIs and PIs drug groups, respectively. Three patients had NRTIs+NNRTs resistance mutations (M184V+K103N) as multi-class drug resistance. However, thymidine analogue resistance mutations (TAMs) determined two distinct genotypic profiles in the HIV-1 reverse transcriptase: TAM1: M41L, L210W and T215Y, and TAM2: D67N, K70R, K219E/Q, and T215F. The prevalence of TAM1 and TAM2 were 7.7% (60/774) and 4.3% (34/774), respectively. CONCLUSIONS The TDRMs prevalence of antiretroviral naïve HIV-1 infected patients may be suggested current situation of Turkey. These long-term and large-scale results show that the resistance testing must be an integral part of the management of HIV infection in Turkey.

UI MeSH Term Description Entries

Related Publications

Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
HIV-1 Transmitted Drug Resistance Mutations in Newly Diagnosed Antiretroviral-Naive Patients in Turkey.
January 2016, AIDS research and human retroviruses,
Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
Transmitted antiretroviral drug resistance among newly HIV-1 diagnosed young individuals in Kampala.
April 2011, AIDS (London, England),
Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
Transmitted HIV type 1 drug resistance in newly diagnosed Cuban patients.
February 2013, AIDS research and human retroviruses,
Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
HIV-1 Transmitted Drug Resistance Mutations in Recently Diagnosed Antiretroviral-Naive Patients in Belém, Pará, Northern Brazil.
February 2019, AIDS research and human retroviruses,
Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
Low prevalence of transmitted drug resistance among newly diagnosed HIV-1 patients in Latvia.
December 2010, Journal of medical virology,
Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
Prevalence of Transmitted HIV drug resistance in antiretroviral treatment naïve newly diagnosed individuals in China.
August 2018, Scientific reports,
Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
Transmitted drug resistance to rilpivirine in newly diagnosed antiretroviral naive adults.
January 2015, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases,
Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
Transmitted antiretroviral drug resistance in individuals with newly diagnosed HIV infection: South Carolina 2005-2009.
February 2011, Southern medical journal,
Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
Prevalence and predictors of antiretroviral drug resistance in newly diagnosed HIV-1 infection.
March 2007, The Journal of antimicrobial chemotherapy,
Murat Sayan, and Fatma Sargýn, and Dilara Inan, and Dilek Yýldýz Sevgi, and Aysel Kocagül Celikbas, and Kadriye Yasar, and Figen Kaptan, and Selda Sayýn Kutlu, and Nuriye Tasdelen Fýsgýn, and Ayse Inci, and Nurgül Ceran, and Ylkay Karaoðlan, and Atahan Cagatay, and Mustafa Kemal Celen, and Suda Tekin Koruk, and Bahadýr Ceylan, and Taner Yýldýrmak, and Halis Akalýn, and Volkan Korten, and Ayse Willke
Prevalence of antiretroviral drug resistance mutations and HIV-1 non-B subtypes in newly diagnosed drug-naïve patients in Slovenia, 2000-2004.
June 2006, Virus research,
Copied contents to your clipboard!