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Mitogenic concentrations of recombinant acidic or basic fibroblast growth factor (FGF) stimulated the accumulation of [3H]inositol phosphates ([3H]IPs) in Swiss 3T3 cells pre-labelled for 48 h with [3H]inositol. Maximal effects were obtained at 0.3 ng/ml and 3 ng/ml for basic and acidic FGF, respectively. Higher doses of either factor led to a diminished stimulation. FGF also stimulated 45Ca2+ release from cells pre-labelled with the isotope. However, FGF-stimulated production of [3H]IPs and release of 45Ca2+ exhibited marked differences when compared with the responses to the peptide mitogen bombesin; the FGF responses were markedly slower and were not inhibited by phorbol esters.
K D Brown, and
D M Blakeley, and
D R Brigstock
January 1994,
Biochimica et biophysica acta,
K D Brown, and
D M Blakeley, and
D R Brigstock
December 1989,
The Biochemical journal,
K D Brown, and
D M Blakeley, and
D R Brigstock
October 1987,
Biochimica et biophysica acta,
K D Brown, and
D M Blakeley, and
D R Brigstock
January 1987,
The Journal of biological chemistry,
K D Brown, and
D M Blakeley, and
D R Brigstock
April 1991,
Biochemical Society transactions,
K D Brown, and
D M Blakeley, and
D R Brigstock
November 1981,
Biochemical and biophysical research communications,
K D Brown, and
D M Blakeley, and
D R Brigstock
October 1985,
FEBS letters,
K D Brown, and
D M Blakeley, and
D R Brigstock
October 1997,
Journal of biochemistry,
K D Brown, and
D M Blakeley, and
D R Brigstock
April 1988,
The EMBO journal,
K D Brown, and
D M Blakeley, and
D R Brigstock
April 1985,
Biochemical and biophysical research communications,
