-transparent.png){kind=logo}
The effects of a novel polypeptide, pancreatic spasmolytic polypeptide (PSP) on a colon carcinoma cell line (HCT 116) were examined. PSP stimulated the incorporation of [3H]thymidine into HCT 116 cells as well as cell proliferation in a dose-dependent manner. Maximal increase in [3H]thymidine incorporation of 50-60% occurred at 3-300 microM PSP. The VIP-mediated-increase in cAMP levels was reduced by PSP at greater than 1 microM concentrations. PSP is highly homologous to the estrogen-induced pS2 protein in MCF-7 breast cancer cells. We find that PSP also enhanced [3H]thymidine incorporation in MCF-7 cells. These findings indicate for the first time that PSP has growth stimulatory properties.
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
June 1992,
Biochemical and biophysical research communications,
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
January 1992,
Journal of cellular physiology,
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
April 1980,
Endocrinologia japonica,
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
October 1978,
Life sciences,
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
January 1988,
Regulatory peptides,
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
November 1985,
Regulatory peptides,
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
March 1982,
Regulatory peptides,
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
January 1996,
European journal of biochemistry,
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
March 1985,
Biochimica et biophysica acta,
N M Hoosein, and
L Thim, and
K H Jørgensen, and
M G Brattain
October 1993,
Journal of Osaka Dental University,
