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OBJECTIVE To explore the expression of cyclophilin A (CypA) in esophageal tissues and its clinical significance. METHODS Expression of CypA was detected in 236 esophageal cancer tissues and 236 normal tissues by using an immunohistochemical method, and the relationship between CypA expression and clinical outcomes was observed. RESULTS There were 166 patients with high expression of CypA (70.23%) and a higher expression in 69.3% of males and 73.3% in females. The CypA expression was irrelevant to age, tumor location, lymph node metastasis, and tumor differentiation degree. The Kaplan-Meier survival curve analysis showed that the expression of CypA was associated with the prognosis of patients with esophageal squamous cell carcinoma. CONCLUSIONS The poor prognosis of esophageal cancer patients was associated with high expression of CypA.
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November 2011,
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology,
Ming-Xiang Feng, and
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January 2018,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
Ming-Xiang Feng, and
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September 2019,
Mathematical biosciences and engineering : MBE,
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Zhonghua zhong liu za zhi [Chinese journal of oncology],
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February 2017,
Molecular medicine reports,
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January 2015,
Neoplasma,
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March 2017,
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June 2011,
World journal of gastroenterology,
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