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Plasma and Intracellular Antiretroviral Concentrations in HIV-Infected Patients under Short Cycles of Antiretroviral Therapy. 2014
Laura Zehnacker, and
Emuri Abe, and
Dominique Mathez, and
Jean-Claude Alvarez, and
Jacques Leibowitch, and
Stéphane Azoulay
Institut de Chimie de Nice UMR 7272, Université Nice Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France.
Study of plasma and intracellular concentrations of atazanavir, lopinavir, nevirapine, and efavirenz was conducted on 48 patients under short cycles of antiretroviral therapy. Intracellular concentrations (IC) were still measurable for all drugs after 85 h or 110 h drug intake despite the absence of drug in plasma for atazanavir and lopinavir. A linear relationship between plasma and intracellular efavirenz was observed. Further studies to fully understand the impact of IC in the intermittent antiviral treatment are required.
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