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A 40-year old homosexual AIDS patient recovering from a Pneumocystis carinii pneumonia developed a Cryptococcus neoformans infection with involvement of the central nervous system (CNS) which could be treated successfully with amphotericin B and flucytosine. After a symptom-free interval of 4 1/2 months, a new acute fatal disease of the CNS did not reveal a cryptococcosis relapse but a necrotizing Toxoplasma encephalitis, a cytomegalovirus infection and striking cultural findings of Staphylococcus aureus in all organs examined. Neither by culture nor by histology Cr. neoformans could be detected in the CNS or in the other organs examined. The temporal course of the Cr. neoformans infection and its specific diagnosis are commented. It is demonstrated that (during or after successful therapy of Pneumocystis carinii pneumonia) a specific cultural examination of specimens from the respiratory tract for Cr. neoformans is needed, in order to recognize a Cr. neoformans infection in its primary stage, i.e. before hematogenous dissemination of Cr. neoformans leading to the secondary stage of the infection.
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
February 1986,
Klinische Wochenschrift,
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
July 2018,
The New England journal of medicine,
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
May 1984,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
June 2007,
Medicina clinica,
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
April 1960,
Schweizerische medizinische Wochenschrift,
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
January 1973,
Lijecnicki vjesnik,
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
July 1971,
Deutsche medizinische Wochenschrift (1946),
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
January 1954,
Delaware state medical journal,
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
June 2009,
Investigacion clinica,
W G Zoller, and
H Kellner, and
F D Goebel, and
K Schmiedtke, and
B Holecek, and
F Staib, and
M Seibold, and
N Zöllner
September 1988,
Der Nervenarzt,
