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Monoclonal antibody c143 against tumor-associated antigen (TAA) expressed on bovine leukemia cells was conjugated to liposomes containing adriamycin (ADM), and therapeutic effects of conjugates were examined in leukemic or preleukemic cows to prevent the progression of the disease. Five cows with TAA-positive in their peripheral blood lymphocytes were divided into two groups. Each group of cows received 4 injections of ADM alone (0.4 mg/kg) or c143-conjugated liposomes containing the same dose of ADM (L-AMD-c143) through the jugular vein at about 4 day intervals. In three animals treated with L-ADM-c143, the TAA-positive cells gradually decreased with treatment and finally two animals became TAA-negative during a 6 week period and a 14 week period after treatment, respectively. In the control, two animals treated with ADM alone showed only a slight decrease of TAA-positive cells.
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
November 1986,
Japanese journal of cancer research : Gann,
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
August 1987,
Cancer research,
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
April 1986,
Nihon Geka Gakkai zasshi,
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
March 1991,
Nihon Geka Gakkai zasshi,
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
June 1989,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
May 2012,
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition,
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
November 1998,
Japanese journal of cancer research : Gann,
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
November 1983,
Cancer research,
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
September 1994,
Zhonghua yi xue za zhi,
M Onuma, and
Y Yasutomi, and
M Yamamoto, and
S Watarai, and
T Yasuda, and
Y Kawakami
January 1992,
Yao xue xue bao = Acta pharmaceutica Sinica,
