-transparent.png){kind=logo}
Among mutants of Streptomyces coelicolor A3(2) studied which were sensitive to chloramphenicol (Cmls), strains sensitive to a number of antibiotics (ristomycin, tetracycline, polymyxin, lincomycin) amount of 46%. Antibiotic-sensitive mutants are capable to form different classes of resistant revertants with frequency varying from 10(-2) to 10(-6) in independent strains. Ristomycin-sensitive clones (Rims) have been found to occur with high frequency in Cmls strains and Cmlr revertants. Mutations mediating the Rims phenotype are mapped in a locus linked to the gene for resistance to chloramphenicol. The results obtained are discussed, in accordance with the notion about possible role of cml mutation in induction of secondary mutational changes in the genome of S. coelicolor A3(2).
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
January 2008,
Mikrobiologiia,
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
July 1991,
Gene,
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
January 1979,
Genetika,
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
July 1977,
Journal of bacteriology,
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
December 2013,
Molecular bioSystems,
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
March 2008,
The Journal of biological chemistry,
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
June 1994,
Gene,
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
February 1977,
Journal of general microbiology,
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
September 2008,
The Journal of biological chemistry,
V A Fedorenko, and
L I Starodubtseva, and
S A Zavorotnaia, and
N D Lomovskaia, and
V N Danilenko
January 2013,
Bioscience, biotechnology, and biochemistry,
