Biomaterial Database

Regulation of extrasynaptic glutamate levels as a pathophysiological mechanism in disorders of motivation and addiction. 2015

Robert E McCullumsmith, and Gerard Sanacora

Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

UI	MeSH Term	Description	Entries
D009042	Motivation	Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.	Incentives,Disincentives,Expectations,Disincentive,Expectation,Incentive,Motivations
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013569	Synapses	Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.	Synapse
D016739	Behavior, Addictive	The observable, measurable, and often pathological activity of an organism that portrays its inability to overcome a habit resulting in an insatiable craving for a substance or for performing certain acts. The addictive behavior includes the emotional and physical overdependence on the object of habit in increasing amount or frequency.	Addictive Behavior,Addictive Behaviors,Behaviors, Addictive
D051247	Sodium-Glucose Transport Proteins	Monosaccharide transport proteins that function as active symporters. They utilize SODIUM or HYDROGEN IONS to transport GLUCOSE across CELL MEMBRANES.	Glucose-Sodium Transport System,SGLT Protein,Sodium Glucose Cotransporter,Sodium Glucose Transporter,Sodium-Glucose Transport Protein,Glucose Sodium Transport System,SGLT Proteins,Sodium Glucose Cotransporters,Sodium Glucose Transport System,Sodium Glucose Transporters,Sodium-Glucose Transport System,Sodium-Sugar Transporter,Cotransporter, Sodium Glucose,Glucose Cotransporter, Sodium,Glucose Cotransporters, Sodium,Glucose Transporter, Sodium,Glucose Transporters, Sodium,Protein, SGLT,Protein, Sodium-Glucose Transport,Sodium Glucose Transport Protein,Sodium Glucose Transport Proteins,Sodium Sugar Transporter,Transport Protein, Sodium-Glucose,Transporter, Sodium Glucose,Transporter, Sodium-Sugar
D018698	Glutamic Acid	A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.	Aluminum L-Glutamate,Glutamate,Potassium Glutamate,D-Glutamate,Glutamic Acid, (D)-Isomer,L-Glutamate,L-Glutamic Acid,Aluminum L Glutamate,D Glutamate,Glutamate, Potassium,L Glutamate,L Glutamic Acid,L-Glutamate, Aluminum