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We have developed and tested a system for providing automatic control of neuromuscular block with atracurium. The degree of neuromuscular block was monitored in the small muscles of the hand using a Datex Relaxograph, and the signal was used as the controlled variable for a proportional plus integral controller. A preloaded integral was used to shorten the period of stabilization. The system was tested in 36 patients undergoing surgery and found to produce stable block. For a target T1 of 20% of control value, the mean block was 18.7 (SD 1.3) % of baseline T1 and the mean consumption of atracurium was 5.39 (SD 1.23) micrograms kg-1 min-1. The block was sufficiently stable to act as a background for studies of pharmacological and physiological interactions with atracurium.
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
September 1997,
Medical & biological engineering & computing,
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
January 1986,
Minerva anestesiologica,
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
July 1989,
Anaesthesia,
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
June 1999,
Computers and biomedical research, an international journal,
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
January 1985,
Annales francaises d'anesthesie et de reanimation,
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
January 1990,
Research in veterinary science,
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
June 1989,
British journal of anaesthesia,
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
October 1992,
Acta anaesthesiologica Scandinavica,
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
March 1985,
European journal of anaesthesiology,
A D MacLeod, and
A J Asbury, and
W M Gray, and
D A Linkens
November 1997,
Acta anaesthesiologica Scandinavica,
