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A neurotoxin 6-hydroxydopamine (6-OHDA) was introduced to 1, 2 and 3 day old male Wistar rats. Falck-Hillarp histochemical fluorescent method was used to analyze hypothalamic and hypophysial structures containing catecholamines. Statistically reliable decrease in catecholamine fluorescence intensity in hypothalamus and hypophysis, accumulation of catecholamines in nerve cells of supraoptic nucleus and in tanycytes of median eminence differed in 25- and 90-days rats. Disturbance of catecholaminergic systems of hypothalamus and hypophysis induced by neonatal introduction of 6-OHDA leads to reliable relaxation of orienting reaction and deep violation of learning that becomes stronger with age.
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
May 1985,
Experimental neurology,
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
December 1973,
Archives internationales de pharmacodynamie et de therapie,
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
December 1985,
Experimental neurology,
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
January 1975,
Pharmacology, biochemistry, and behavior,
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
August 1980,
Science (New York, N.Y.),
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
January 1975,
Pharmacology, biochemistry, and behavior,
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
June 1996,
Doklady Akademii nauk,
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
January 1985,
Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova,
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
January 1982,
Drug and alcohol dependence,
M S Konstantinova, and
T P Semenova, and
N I Grishchenko, and
E A Gromova, and
A L Polenov
June 1991,
Journal of developmental physiology,
