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The possible role of human papilloma virus (HPV) and herpes simplex virus type 2 (HSV-2) in the viral etiology of cervical carcinoma was investigated a series of cervical lesions were studied for the presence of HPV and HSV-2 DNA sequences as well as HPV and HSV-2 antigens by DNA dot blot hybridization technique and high-specificity PAP staining method. The results obtained were correlated with the histologic diagnosis. HPV 16 DNA sequences detected in cervical carcinoma biopsies were 43%, whereas HSV-2 DNA sequences were only 8%. HPV antigens detected in cervical dysplasia were 31%, whereas those detected in cervical carcinoma and cervicitis were the least. HSV-2 antigens were detected in chronic cervicitis, dysplasia and cervical carcinoma. The difference in positive rate between the cervical carcinoma and cervicitis groups was statistically significant, (chi-square test, P less than 0.01). No HPV DNA and HSV-2 DNA sequences were found in the same specimen, although both HPV DNA sequences and HSV-2 antigens were found in the same sample in some cases. The results indicate that the viral etiology of cervical carcinoma may be multifactorial. Both HSV-2 and HPV may be associated with cervical carcinoma, but the mechanisms involved are different. HSV-2 and HPV may act synergistically in the development of cervical carcinoma.
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
January 1974,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
March 1989,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
September 1986,
Clinical obstetrics and gynecology,
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
January 1992,
Journal of experimental pathology,
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
June 1981,
European journal of cancer,
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
January 1987,
Advances in cancer research,
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
October 1981,
Current problems in cancer,
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
January 1984,
Clinics in dermatology,
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
December 1972,
Deutsche medizinische Wochenschrift (1946),
X J Meng, and
Y Sun, and
M H Chen, and
Z H Liu, and
Y X Zhang, and
X Z Li, and
K Li, and
R C Han, and
J Y Si, and
L Y Hu
September 1981,
Akusherstvo i ginekologiia,
