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We describe concise and efficient synthesis of biologically very important 3'-O-tetraphosphates namely 2'-deoxyadenosine-3'-O-tetraphosphate (2'-d-3'-A4P) and 2'-deoxycytidine-3'-O-tetra-phosphate (2'-d-3'-C4P). N(6)-benzoyl-5'-O-levulinoyl-2'-deoxyadenosine was converted into N(6)-benzoyl-5'-O-levulinoyl-2'-deoxyadenosine-3'-O-tetraphosphate in 87% yield using a one-pot synthetic methodology. One-step concurrent deprotection of N(6)-benzoyl and 5'-O-levulinoyl groups using concentrated aqueous ammonia resulted 2'-d-3'-A4P in 74% yield. The same synthetic strategy was successfully employed to convert N(4)-benzoyl-5'-O-levulinoyl-2'-deoxycytidine into 2'-d-3'-C4P in 68% yield.
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
January 2012,
Nucleosides, nucleotides & nucleic acids,
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
March 2006,
Bioorganic & medicinal chemistry,
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
January 2006,
Nucleosides, nucleotides & nucleic acids,
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
April 1997,
The Journal of organic chemistry,
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
January 2001,
Nucleosides, nucleotides & nucleic acids,
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
January 2007,
Nucleic acids research,
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
February 2004,
Chemical research in toxicology,
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
January 1999,
IARC scientific publications,
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
December 2008,
Nucleosides, nucleotides & nucleic acids,
Anilkumar R Kore, and
Bo Yang, and
Balasubramanian Srinivasan, and
Annamalai Senthilvelan
December 2018,
Current protocols in nucleic acid chemistry,
