-transparent.png){kind=logo}
OBJECTIVE To assess the anti-cancer effect of lobaplatin on human gastric cancer cells, and to explore the underlying molecular mechanisms. METHODS The human gastric cancer cell lines MKN-28, AGS and MKN-45 were used. The cytotoxicity of lobaplatin was detected using an MTS cell proliferation assay. Flow cytometry was used to detect cell apoptosis using Annexin V-FITC Apoptosis Detection Kit. The expression of apoptosis-regulated genes was examined at the protein level using Western blot. RESULTS Lobaplatin inhibited the proliferation of human gastric cancer cells and induced apoptosis, which may be associated with the up-regulation of Bax expression, poly(ADP-ribose) polymerase (PARP) cleavage, p53 expression and the reduction of Bcl-2 expression. CONCLUSIONS The cytotoxicity of lobaplatin may be due to its ability of inducing apoptosis of gastric cancer cells, which would support the potential use of lobaplatin for the therapy of gastric cancer.
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
January 2023,
Combinatorial chemistry & high throughput screening,
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
March 2011,
Cancer letters,
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
January 2018,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
January 2013,
Cancer biotherapy & radiopharmaceuticals,
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
March 1998,
Methods and findings in experimental and clinical pharmacology,
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
March 2013,
Planta medica,
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
January 2020,
Nutrition and cancer,
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
November 2018,
Phytotherapy research : PTR,
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
January 2020,
Cancer management and research,
Chu-Yang Yin, and
Xiao-Lin Lin, and
Lei Tian, and
Ming Ye, and
Xin-Ying Yang, and
Xiu-Ying Xiao
January 2016,
Journal of Cancer,
