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The ability of tamoxifen, an antiestrogen agent, to antagonise the striatal dopamine receptor hyperactivity induced in rats by chronic treatment with 17 beta-estradiol and 2-hydroxyestradiol or with two receptor blockers (haloperidol and sulpiride) was compared. It was found that tamoxifen antagonised both the increase in [3H]spiperone binding sites and the stereotyped behaviour induced by apomorphine in animals treated with the two steroids but had no effect in animals receiving the two dopamine blockers. These results run counter to the view that introduction of a catechol group in a steroid molecule is of decisive importance in the induction of striatal dopamine receptor hypersensitivity.
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
September 1980,
Neuropharmacology,
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
December 1993,
The Journal of steroid biochemistry and molecular biology,
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
January 1984,
Psychopharmacology,
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
April 1984,
The Journal of pharmacology and experimental therapeutics,
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
September 1992,
Synapse (New York, N.Y.),
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
January 1986,
Psychopharmacology,
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
January 1988,
Psychopharmacology,
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
January 1986,
Acta physiologica Scandinavica,
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
August 1980,
European journal of pharmacology,
C Ferretti, and
P Ghi, and
M Blengio, and
G Gaietta, and
G Barrera, and
E Genazzani
April 1992,
Annals of neurology,
