-transparent.png){kind=logo}
It is established that the new compound, 9-[2-(4-isopropylphenoxy)ethyl]adenine (9-IPE-adenine) in a dose of 10 mg/kg per day produces neuroprotective effect in rats with brain ischemia model. 9-IPE-adenine decreased the neurologic deficiency 1.2 times more effectively (p < 0.05) than the reference drug mexidol in analogous dose, and had equal effect with this drug at 25 mg/kg per day on the neurologic deficiency and survival of animals. Electrophysiological studies in hippocampal slices in rats showed that 9-IPE-adenine depressed orthodromic population spikes in CA1 area by 42 ± 4%. Non-competitive antagonist of NMDA receptor complex MK-801, in contrast to D-AP5 (competitive NMDA receptor antagonist) and CNQX (competitive AMPA receptor antagonist), enhanced the depressive effect of the new drug more than two times. These ese results are indicative of the ability of 9-IPE-adenine to modulate the ion channel of NMDA receptor complex.
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
January 1979,
Farmakologiia i toksikologiia,
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
April 1971,
Ceskoslovenska farmacie,
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
July 1958,
Bollettino della Societa italiana di biologia sperimentale,
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
July 1995,
General pharmacology,
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
September 1979,
Bollettino chimico farmaceutico,
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
January 1953,
Therapie,
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
November 1972,
Archives internationales de pharmacodynamie et de therapie,
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
January 1969,
Ceskoslovenska farmacie,
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
January 2016,
Eksperimental'naia i klinicheskaia farmakologiia,
Iasnetsov, and
A A Ozerov, and
V G Motin, and
Vik V Iasnetsov, and
S K Karsanova, and
Iu V Ivanov, and
N A Chel'naia
April 1959,
Archives internationales de pharmacodynamie et de therapie,
